Prostaglandin D2 reduces intraocular pressure.

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Prostaglandin D2 reduces intraocular pressure.

When PGD2 was topically applied to the rabbit eye a reduction of intraocular pressure (IOP) was observed within 30 min. The IOP reduction lasted throughout the observation period of 7 hours. No increase of IOP was observed during the period. The effect of PGD2 was dose-dependent (0.4 microgram to 250 micrograms), and the minimum effective dose was estimated to be 2.0 micrograms. The application...

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Prostaglandin synthesis, inhibition, and intraocular pressure.

Arachidonic acid, a precursor of prostaglandin E!} administered topically to rabbit and monkey eyes in concentrations of 0.2 to 20 per cent, or intravenously to rabbits in doses of 10 to 20 mg., produced a significant elevation of intraocular pressure. A dose-response relationship was demonstrated. Facility of outflow and anterior chamber aqueous protein were significantly higher in eyes treate...

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Increase of intraocular pressure after topical administration of prostaglandin analogs.

ReportofaCase.A29-year-oldwoman had retinitis pigmentosa with typical ophthalmoscopic findings, a ring scotoma, and a flat electroretinogram. Juvenile glaucoma was diagnosed at the age of 12 years. Becauseof thecharacteristicmalformation of the anterior segment it was classifiedasRiegersyndrome.Theinitial IOP at the time of glaucoma detection was 50 mm Hg. Both eyes underwentElliotoperation.The...

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Increase of Intraocular Pressure After Topical Administration of Prostaglandin Analogs

ReportofaCase.A29-year-oldwoman had retinitis pigmentosa with typical ophthalmoscopic findings, a ring scotoma, and a flat electroretinogram. Juvenile glaucoma was diagnosed at the age of 12 years. Becauseof thecharacteristicmalformation of the anterior segment it was classifiedasRiegersyndrome.Theinitial IOP at the time of glaucoma detection was 50 mm Hg. Both eyes underwentElliotoperation.The...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1988

ISSN: 0007-1161

DOI: 10.1136/bjo.72.6.461